The chemotherapeutic drug 5-fluorouracil (5-FU) is a well-known treatment option reserved for recalcitrant HTSs and keloid lesions. 5-FU is a safe and practical alternative for the treatment of HTSs and keloids as it may substantially improve the appearance of proliferative scars and reduce the chance of recurrence.
This therapeutic option is most effective in conjunction with adjuvant therapy such as corticosteroids. These injections are often part a treatment plan for keloids. When injected into the keloid, these medicines help to shrink the scar.
Patients usually receive a series of injections once every three to four weeks. On average, patients return about four times for these injections. The first injections tend to relieve symptoms and make the keloid feel softer.